Target Indication: Systemic Gram positive infections e.g. Infectious Endocarditis and Healthcare
Associated Pneumonia (HCAP)
Stage: Preclinical – Entering Phase I in 2014/2015
Chemistry: First in class small molecule <500MWT
Potency: MIC of <1.0µg/ml against multi-drug resistant Staph. Aureus, VRE and Streptococci
Antibiotic spectrum: Gram-positive VRE, Streptococci, MRSA, MSSA
Safety: Low toxicity
PK/PD: PK profiles in-vivo, with an efficacy of 0.125 mg/kg. The PK profile allows improved in vivo efficacy with around 2.5 hour half life time in-vivo (index 10x above MIC), by an once a day administration.
Production: Low production costs (cheap and easy chemistry)
Mode of action: Addresses multiple targets – No cross-resistance expected
For more information please email: [email protected]